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TARGETMOL CHEMICALS INC ARS-853 5MG
Also available in 1mg 10mg 25mg 50mg 100mg 500mg and bulk. Please contact Fisher for quotes. ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM) a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cellspurity: 98%
Medchemexpress LLC ARS-1630 | 1698055-86-5 | 430.84 | 1 ML
ARS-1630 is a novel inhibitor of mutant K-ras G12C, as described in patent WO 2015054572 A1. It is intended for research use only and is the less active enantiomer of ARS-1620.
- Inhibits mutant K-ras G12C.
- Less active enantiomer of ARS-1620.
- Intended for research use only.
- Purity of 98.1%.
- Provided as a 10 mM solution in 1 mL DMSO.
- Stable for 2 years at -80°C or 1 year at -20°C in solvent; aliquot to prevent freeze-thaw inactivation.
Medchemexpress LLC ARS-853 | 1629268-00-3 | 98.39% | 432.94 | 500 MG
ARS-853 is a cell-active, selective, covalent KRAS G12C inhibitor. It inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein, thereby preventing its activation. This compound is intended for research use only.
- Cell-active and selective KRAS G12C inhibitor.
- Inhibits mutant KRAS-driven signaling.
- Prevents activation of GDP-bound oncoprotein.
- Reduces GTP-bound KRAS levels by more than 95% at 10 μM in KRASG12C-mutant lung cancer cells.
- Inhibits proliferation, effector signaling, and induces apoptosis in KRASG12C mutant cell lines.
Medchemexpress LLC ARS-853 | 1629268-00-3 | 98.39% | 432.94 | 25 MG
ARS-853 is a cell-active, selective, and covalent KRAS G12C inhibitor with an IC50 of 2.5 μM. It inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein, thereby preventing its activation.
- Selective KRAS G12C inhibition: designed to bind to KRASG12C with high affinity.
- Potent cellular activity: reduces GTP-bound KRAS levels by over 95% at 10 μM in KRASG12C-mutant lung cancer cells.
- Antiproliferative effects: inhibits proliferation in KRASG12C mutant lung cancer cell lines with an IC50 of 2.5 μM.
- Induces apoptosis in four KRASG12C mutant cell lines.
- Suppresses effector signaling: completely suppresses the effects of exogenous KRASG12C expression on KRAS-GTP levels, KRAS-BRAF interaction, and ERK signaling.
- Intended for research use only.
Medchemexpress LLC Ars-853 | 1629268-00-3 | 98.39% | 432.94 | 1 ML
ARS-853 is a cell-active, selective, covalent KRAS G12C inhibitor with an IC50 of 2.5 μM. It inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation.
- Cell-active, selective, covalent KRAS G12C inhibitor.
- IC50 of 2.5 μM for KRAS(G12C).
- Inhibits mutant KRAS-driven signaling.
- Reduces GTP-bound KRAS levels by more than 95% at 10 μM in KRASG12C-mutant lung cancer cells.
- Inhibits proliferation with an IC50 similar to its target inhibition IC50.
- Selectively reduces KRAS-GTP levels and RAS-effector signaling in KRASG12C-mutant cells.
- Induces apoptosis in four KRASG12C mutant cell lines.
Grainger G3262 Level Gauge HDPE D 18in
The AT-A-GLANCE Level Gauge For 18 in Container is a reusable level indicator that allows you to visually monitor liquid levels in 18 inch diameter tanks or containers. It has a durable polypropylene construction and features large, easy-to-read level markers from FULL to ADD in half inch increments. This device allows operators to quickly check fill levels without opening or unsealing containers. It can withstand temperatures up to 180°F. The AT-A-GLANCE level gauge is an economical solution for monitoring fluid levels in industrial applications.